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What the Research Shows Key Preclinical Studies Research published in the journal Osteoarthritis and Cartilage provided some of the most significant evidence for AOD-9604's joint health potential

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A recent finding shows that cells lacking ATAD1, an AAA + ATPase that removes substrate proteins directly from the OMM for degradation, are hypersensitive to proteasomal inhibition (Winter et al., 2022)

However, its clinical benefit is limited due to the strong toxicity and the limited number of patients who benefit from it, although approximately 10% of patients do achieve a durable response